Journal of Medicinal Chemistry · 1975 · 26 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyStructure-activity RelationshipsSynthetic Medicinal ChemistryAntiviral AgentsAntiviral PharmacologyStructure-activity Relationship AnalysisAntiviral Natural ProductsAntiviral Structure-activity RelationshipsChemical Structure-activity RelationshipsQuinoline ChemistryQuinoline Synthesis
Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.