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Antiviral quinolinehydrazones. Modified Free-Wilson analysis
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1975
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Medicinal ChemistryEighty-four 4-QuinolinehydrazonesFree-wilson ApproachBiochemistryAntiviral ActivityMedicineNatural SciencesAntiviral Drug DevelopmentAntiviral TherapyAntiviral QuinolinehydrazonesAntiviral DrugPharmacologyAntiviral CompoundPharmaceutical ChemistryDrug Discovery
Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.