Tristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Masatsugu Ema, Shin-ichiro Taya, Noboru Yokotani et al. · Proceedings of the National Academy of Sciences · 1997 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +13

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Fang Yu, Sarah B. White, Quan Zhao et al. · Proceedings of the National Academy of Sciences · 2001 · 793 citations · Full text

Medicine, Molecular Biology, Oncology +14

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Wi S. Lai, Ester Carballo, Julie R. Strum et al. · Molecular and Cellular Biology · 1999 · 728 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells

Tokujiro Uchida, Fabrice Rossignol, Michael A. Matthay et al. · Journal of Biological Chemistry · 2004 · 432 citations · Full text

Life Sciences, Genetics, Molecular Biology +16