C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

Beppino C. Giovanella, John S. Stehlin, Monroe E. Wall et al. · Science · 1989 · 647 citations

Medicine, Oncology, Pharmacology +15

An Activity from Mammalian Cells That Untwists Superhelical DNA—A Possible Swivel For DNA Replication

James J. Champoux, Renato Dulbecco · Proceedings of the National Academy of Sciences · 1972 · 339 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy.

Intisar Husain, James L. Mohler, H F Seigler et al. · PubMed · 1994 · 245 citations

Medicine, Oncology, Pharmacology +13

beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.

C J Li, Lidia Averboukh, Arthur B. Pardee · Journal of Biological Chemistry · 1993 · 218 citations · Full text

Medicine, Biochemistry, Pharmacology +14

Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I

Philippe Pourquier, Li-Ming Ueng, Glenda Kohlhagen et al. · Journal of Biological Chemistry · 1997 · 199 citations · Full text

Life Sciences, Genetics, Molecular Biology +14