Concepedia

Temporal and Spatial Evolution of Therapy-Induced Tumor Apoptosis Detected by Caspase-3–Selective Molecular Imaging

Quang-Dé Nguyen, Ioannis Lavdas, James Gubbins, Graham Smith, Robin Fortt, Laurence Carroll, Martin A. Graham, Eric O. Aboagye

Clinical Cancer Research · 2013 · 55 citations · 20 references

DOI

Abstract

The proapoptotic effects of CPA and birinapant resulted in a time-dependent increase in [(18)F]ICMT-11 uptake detected by PET. [(18)F]ICMT-11-PET holds promise as a noninvasive pharmacodynamic biomarker of caspase-3-associated apoptosis in tumors.

References

20

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger, Andrew J. Rowan, Stuart Horswell et al. · New England Journal of Medicine · 2012 · 7.6K citations · Full text

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Guido Kroemer, Lorenzo Galluzzi, Peter Vandenabeele et al. · Cell Death and Differentiation · 2008 · 3.3K citations · Full text

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Guidelines for the welfare and use of animals in cancer research

Paul Workman, Eric O. Aboagye, Frances R. Balkwill et al. · British Journal of Cancer · 2010 · 1.4K citations · Full text

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Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung Cancer

Jian-Mei Hou, Matthew Krebs, Lee Lancashire et al. · Journal of Clinical Oncology · 2012 · 833 citations · Full text

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

Michael J. Lee, Albert S. Ye, Alexandra K. Gardino et al. · Cell · 2012 · 676 citations · Full text

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