Microvascular permeability to macromolecules in human melanoma xenografts assessed by contrast-enhanced MRI—intertumor and intratumor heterogeneity

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

Clifford S. Patlak, Ronald G. Blasberg, Joseph D. Fenstermacher · Journal of Cerebral Blood Flow & Metabolism · 1983 · 3.6K citations · Full text

Pharmacy, Neuroscience, Pharmacokinetics +14

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

Susan K. Hobbs, Wayne L. Monsky, Fan Yuan et al. · Proceedings of the National Academy of Sciences · 1998 · 2.4K citations

Medicine, Cancer Biology, Oncology +17

Role of extracellular matrix assembly in interstitial transport in solid tumors.

Paolo A. Netti, David A. Berk, Melody A. Swartz et al. · PubMed · 2000 · 1.2K citations · Full text

Natural Sciences, Biophysics, Oncology +17

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

Fan Yuan, Hassan A. Salehi, Yves Boucher et al. · PubMed · 1994 · 470 citations

Medicine, Cancer Biology, Oncology +15