UCS1025A, a Novel Antibiotic Produced by Acremonium sp.

Abstract

In the course of our screening for antitumor antibiotics, two novel compounds, UCS1025A and B, were isolated from Acremonium sp. KY4917. UCS1025A exhibited antimicrobial activity, and antiproliferative activity against humantumor cell lines. In this paper, we describe the taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities ofUCS1025A and B. The cultural and taxonomical characteristics of the