Synthesis of Sphingofungin D and Its Three Diastereomers

Abstract

Sphingofungin D [(2S,3R,4R,5S,14R)-1] and its three diastereomers were synthesized by starting from (R)-1,2-epoxyoctane [(R)-7], 1-heptyne (8) and N-acetyl-D-mannosamine (9).