International Journal of Molecular Sciences · 2014 · 66 citations · 21 references
Life SciencesCancer BiologyOncologyApoptosisCancer PharmacologyMolecular OncologyApoptosis In CancerApoptosis ModulationApoptosis PharmacologyApoptosis RegulationApoptotic SignalingBcl-2 Family ProteinsAnticancer ActivityAnticancer ChemotherapyAnticancer Compound ScreeningApoptotic Signaling In CancerBcl-2 Protein ExpressionBcl-2 Protein RegulationCancer Cell ApoptosisCaspase-mediated Apoptosis
Evidence suggests that phytochemicals can safely modulate cancer cell biology and induce apoptosis. Here, we investigated the anti-cancer activity of morin, a flavone originally isolated from members of the Moraceae family in human leukemic cells, focusing on apoptosis. An anti-cancer effect of morin was screened with several human leukemic cell lines. U937 cells were most sensitive to morin, where it induced caspase-dependent apoptosis in a dose-dependent manner. It also induced loss of MMP (ΔΨm) along with cytochrome c release, down-regulated Bcl-2 protein, and up-regulated BAX proteins. The apoptotic activity of morin was significantly attenuated by Bcl-2 augmentation. In conclusion, morin induced caspase-dependent apoptosis through an intrinsic pathway by upregulating BAD proteins. In addition, Bcl-2 protein expression is also important in morin-induced apoptosis of U937 cells. This study provides evidence that morin might have anticancer properties in human leukemic cells.
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Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Elizabeth Yang, Jiping Zha, Jennifer Jockel et al. · Cell · 1995 · 2.1K citations · Full text
Distinctive Antioxidant and Antiinflammatory Effects of Flavonols
Lisu Wang, Yi-Chen Tu, Jing-Ting Hung et al. · Journal of Agricultural and Food Chemistry · 2006 · 385 citations