Concepedia

TAK1–TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-κB signaling pathways

Hiroaki Sakurai, Akito Nishi, Naoya Sato, Junko Mizukami, Hidetaka Miyoshi, Takahisa Sugita

Biochemical and Biophysical Research Communications · 2002 · 81 citations · 24 references

DOI

Concepts

References

24

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

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Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

Kyoko Shirakabe, Hiroshi Shibuyà, Kenji Irie et al. · Science · 1995 · 1.3K citations

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The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

Jun Ninomiya‐Tsuji, Kazuya Kishimoto, Atsushi Hiyama et al. · Nature · 1999 · 1.2K citations

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The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Tohru Ishitani, Jun Ninomiya‐Tsuji, Shin‐ichi Nagai et al. · Nature · 1999 · 619 citations

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TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

Giichi Takaesu, Satoshi Kishida, Atsushi Hiyama et al. · Molecular Cell · 2000 · 608 citations · Full text

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