Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Margherita Maffei, Jeffrey L. Halaas, Éric Ravussin et al. · Nature Medicine · 1995 · 3.7K citations

Medicine, Endocrinology, Physiology +15

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Michael A. Cowley, James L. Smart, Marcelo Rubinstein et al. · Nature · 2001 · 2.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Patricia A. Heine, Julia A. Taylor, Gary A. Iwamoto et al. · Proceedings of the National Academy of Sciences · 2000 · 1.3K citations · Full text

Life Sciences, Endocrinology, Physiology +8

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

Sonia Dupont, Andrée Krust, Anne Gansmüller et al. · Development · 2000 · 1.1K citations

Medicine, Endocrinology, Gynecology +17

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

Fredrik Lönnqvist, Peter Arner, Louise Nordfors et al. · Nature Medicine · 1995 · 709 citations

Life Sciences, Genetics, Molecular Biology +14