Characterization of a series of vacuolar type H+-ATPase inhibitors on CTL-mediated cytotoxicity

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

Peter J. Peters, Jannie Borst, Viola Oorschot et al. · The Journal of Experimental Medicine · 1991 · 719 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Hybrid antibodies can target sites for attack by T cells

Uwe D. Staerz, Osami Kanagawa, Michael J. Bevan · Nature · 1985 · 494 citations

Life Sciences, Immunology, Molecular Biology +14

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

K. U. Bindseil, Emma Jean Bowman, Annette Siebers et al. · Biochemistry · 1993 · 418 citations

Life Sciences, Biochemistry, Molecular Biology +10

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity

Takao Kataoka, N Shinohara, Hajime Takayama et al. · The Journal of Immunology · 1996 · 384 citations · Full text

Life Sciences, Cell Biology, Pharmacology +13