Concepedia

Vacuolar Atpase Function

Vacuolar ATPase Function is a molecular mechanism that belongs to the class of enzyme-mediated ion transport processes, specifically distinguished by its role in acidifying intracellular compartments through the ATP-dependent translocation of protons into the lumen of endosomes and lysosomes to drive endosome maturation and lysosomal trafficking.

1.3K

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5.2K

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1.3K

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2017–2026

168

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Publications

1.3K

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text

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Bafilomycin A1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells.

Akitsugu Yamamoto, Yoshihiro Tagawa, Tamotsu Yoshimori et al. · Cell Structure and Function · 1998 · 1.3K citations

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Lack of Acidification in <i>Mycobacterium</i> Phagosomes Produced by Exclusion of the Vesicular Proton-ATPase

Sheila Sturgill-Koszycki, Paul H. Schlesinger, Prasanta Chakraborty et al. · Science · 1994 · 1.3K citations

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A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

Shoshana Paglin, Timothy Hollister, Thomas Delohery et al. · PubMed · 2001 · 959 citations

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Evolution of the vacuolar H+-ATPase: implications for the origin of eukaryotes.

J. Peter Gogarten, Henrik Kibak, P. Dittrich et al. · Proceedings of the National Academy of Sciences · 1989 · 791 citations · Full text

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Authors

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  1. MF
    Michael Forgac

    Tufts University, United States

    44 publications · 3.6K citations

    39

    h-index

  2. PM
    Patricia M. Kane

    SUNY Upstate Medical University, United States

    36 publications · 3.2K citations

    31

    h-index

  3. TH
    Tom H. Stevens

    University of Oregon, United States

    26 publications · 2.4K citations

    23

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  4. SL
    Stephen L. Gluck

    Washington University in St. Louis, United States

    22 publications · 3.3K citations

    20

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  5. DB
    Dennis Brown

    Massachusetts General Hospital, United States

    20 publications · 1.3K citations

    19

    h-index

1–5 of 5.2K

Institutions

1.3K

  1. Tufts University

    Medford, United States

    39 h-index

    124 publications

    11.6K citations

  2. The University of Osaka

    Osaka, Japan

    30 h-index

    116 publications

    10.6K citations

  3. Harvard University

    Cambridge, United States

    27 h-index

    96 publications

    5.2K citations

  4. University of Toronto

    Toronto, Canada

    24 h-index

    89 publications

    6.1K citations

  5. The University of Tokyo

    Tokyo, Japan

    23 h-index

    62 publications

    4.7K citations

  6. University of California, Santa Cruz

    Santa Cruz, United States

    23 h-index

    103 publications

    16.3K citations

  7. Massachusetts General Hospital

    Boston, United States

    23 h-index

    102 publications

    6.1K citations

  8. Tokyo University of Science

    Tokyo, Japan

    23 h-index

    82 publications

    9K citations

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  1. Journal of Biological Chemistry

    JBC · 247 publications · 23.5K citations

    90

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  2. Proceedings of the National Academy of Sciences

    PNAS · 35 publications · 4.9K citations

    30

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  3. PLANT PHYSIOLOGY

    37 publications · 3.6K citations

    29

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  4. Biochemical Journal

    BJ · 25 publications · 1.2K citations

    23

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  5. The Journal of Cell Biology

    JCB · 22 publications · 3.3K citations

    22

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