Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth

Shiyin Yee · Pharmaceutical Research · 1997 · 1K citations

Pharmacy, Cell Biology, Physiology +13

IAM chromatography: an in vitro screen for predicting drug membrane permeability

Charles Pidgeon, Shaowei Ong, Hanlan Liu et al. · Journal of Medicinal Chemistry · 1995 · 267 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

Raymond T. Bartus, Neil J. Hayward, Peter J. Elliott et al. · Stroke · 1994 · 218 citations

Medicine, Neuroscience, Pharmacology +17

Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular Pathway

Giovanni M. Pauletti, Franklin W. Okumu, Ronald T. Borchardt · Pharmaceutical Research · 1997 · 176 citations

Natural Sciences, Biochemistry, Biophysics +15