Concepedia

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

Diana L. Donnelly‐Roberts, Marian T. Namovic, Bruce W. Surber, Srirajan X. Vaidyanathan, Arturo Perez‐Medrano, Ying Wang, William A. Carroll, Michael F. Jarvis

Neuropharmacology · 2008 · 107 citations · 28 references

DOI

Concepts

References

28

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

The Cytolytic P <sub>2Z</sub> Receptor for Extracellular ATP Identified as a P <sub>2X</sub> Receptor (P2X <sub>7</sub> )

Annmarie Surprenant, Eric Kawashima, R. Alan North et al. · Science · 1996 · 1.7K citations

, , +15

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Iain P. Chessell, Jonathan P. Hatcher, C. Bountra et al. · Pain · 2005 · 784 citations

, , +17

Tissue distribution of the P2X7 receptor

Ginetta Collo, S. Neidhart, Eric Kawashima et al. · Neuropharmacology · 1997 · 498 citations

, , +13

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

Jeffrey M. Labasi, Nina Petrushova, Carol Donovan et al. · The Journal of Immunology · 2002 · 487 citations · Full text

, , +17