Concepedia

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

Chin‐Shiu Huang, Chong‐Kuei Lii, Ai‐Hsuan Lin, Yu‐Wen Yeh, Hsien‐Tsung Yao, Chien‐Chun Li, Tsu‐Shing Wang, Haw‐Wen Chen

Archives of Toxicology · 2012 · 181 citations · 42 references

DOI

Concepts

References

42

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

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Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Jawed Alam, Daniel P. Stewart, Cheri Touchard et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

, , +16

Ferritin: a cytoprotective antioxidant strategem of endothelium.

G. Balla, HS Jacob, József Balla et al. · Journal of Biological Chemistry · 1992 · 1.1K citations · Full text

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Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

David A. Bloom, Anil K. Jaiswal · Journal of Biological Chemistry · 2003 · 518 citations · Full text

, , +16

Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

Stefan W. Ryter, Leo E. Otterbein, Danielle Morse et al. · Molecular and Cellular Biochemistry · 2002 · 494 citations · Full text

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