Riluzole decreases the abstinence syndrome and physical dependence in morphine-dependent mice

SYNTHETIC ANALGESICS. II. DITHIENYLBUTENYL- AND DITHIENYLBUTYLAMINES

Nathan B. Eddy, Dorothy G. Leimbach · Journal of Pharmacology and Experimental Therapeutics · 1953 · 1.8K citations

Medicinal Chemistry, Health Sciences, Pain Medicine +7

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

Évelyne Benoit, Denis Escande · Pflügers Archiv - European Journal of Physiology · 1991 · 224 citations

Hyperpolarization (Biology), Neurophysiology, Medicine +13

Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes

Marc-Williams Debono, Joëlle Le Guern, Thierry Canton et al. · European Journal of Pharmacology · 1993 · 210 citations

Xenopus Oocytes, Molecular Physiology, Hyperpolarization (Biology) +13

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

Wouter Koek, F. C. Colpaert · Journal of Pharmacology and Experimental Therapeutics · 1990 · 202 citations