Proteinase-activated receptor-2 activation participates in allergic sensitization to house dust mite allergens in a murine model

Abstract

PAR2 activation plays a key role during the sensitization phase of our HDM allergy model, leading to increased lung cytokine production and augmented lung reactivity. PAR2 activation is a common mechanism for sensitization to a wide variety of allergens and is therefore a potential pharmacological target to prevent allergy.