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Deficiency of both protein C and protein S in a family with ischemic strokes in young adults
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1994
Year
Vascular DiseaseYoung AdultsIschemic StrokesCerebrovascular DiseaseHyperlipidemiaProtein SS DeficienciesThrombosisVenous ThrombosisHematologyNeurologyPublic HealthNeuropathologyAtherosclerosisIschemic SyndromeInherited DeficienciesMedicineVascular BiologyCerebral Blood FlowArterial ThrombosisEpidemiologyIschemic StrokeCardiovascular DiseaseStroke-related ConditionStroke
Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary embolism, but their role in arterial thrombosis or embolism is controversial. We describe cerebral ischemia in two young women in a family with inherited deficiencies of both proteins C and S and provide evidence that a combined deficiency of proteins C and S may be a high risk factor for ischemic stroke in young adults.