Immature Oxidative Stress Management as a Unifying Principle in the Pathogenesis of Necrotizing Enterocolitis: Insights from an Agent-Based Model

Abstract

Our ABM incorporates known components of NEC and demonstrates that impaired OS management can lead to apoptosis and inflammation of NGECs, rendering the system susceptible to an additional insult involving regionalized mucus barrier failure and TLR-4 activation, which potentiates the necrosis outcome. This type of integrative dynamic knowledge representation can be a useful adjunct to help guide and contextualize research.