Concepedia

Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers

Michael Joyce, Bradley Thomas, Daniel M. Jones, John Law, Rodney S. Russell, Michael Houghton, D. Lorne Tyrrell

Hepatology · 2013 · 61 citations · 20 references

DOI

Abstract

We describe a convenient, cost-effective method to produce hepatocyte-like cells, which produce large amounts of virus that more closely resemble HCV present in serum of infected patients.

References

20

A new mathematical model for relative quantification in real-time RT-PCR

Michael W. Pfaffl · Nucleic Acids Research · 2001 · 34.3K citations · Full text

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

Takaji Wakita, Thomas Pietschmann, Takanobu Kato et al. · Nature Medicine · 2005 · 2.7K citations · Full text

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Complete Replication of Hepatitis C Virus in Cell Culture

Brett D. Lindenbach, Matthew J. Evans, Andrew J. Syder et al. · Science · 2005 · 2.2K citations

Robust hepatitis C virus infection <i>in vitro</i>

Jin Zhong, Pablo Gastaminza, Guofeng Cheng et al. · Proceedings of the National Academy of Sciences · 2005 · 1.7K citations

The lipid droplet is an important organelle for hepatitis C virus production

Yusuke Miyanari, Kimie Atsuzawa, Nobuteru Usuda et al. · Nature Cell Biology · 2007 · 1.2K citations

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