Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

Petra Boukamp, R T Petrussevska, Dirk Breitkreutz et al. · The Journal of Cell Biology · 1988 · 4.1K citations · Full text

Skin Development, Cell Division, Cutaneous Biology +11

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Christopher Baines, Robert A. Kaiser, Nicole H. Purcell et al. · Nature · 2005 · 2.2K citations

Mitophagy, Mitochondrial Function, Biochemistry +10

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Markus Guba, Philipp von Breitenbuch, Markus Steinbauer et al. · Nature Medicine · 2002 · 1.7K citations

Oncology, Angiogenesis, Metastatic Tumor Growth +9

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Takashi Nakagawa, Shigeomi Shimizu, Tetsuya Watanabe et al. · Nature · 2005 · 1.6K citations

Inflammation, Mitophagy, Biochemistry +9

Cyclosporine induces cancer progression by a cell-autonomous mechanism

Minoru Hojo, Takashi Morimoto, Mary A. Maluccio et al. · Nature · 1999 · 1.1K citations

Cancer Immunosurveillance, Signal Transduction, Cell-autonomous Mechanism +6