Concepedia

ATP and GTP as alternative energy sources for vinblastine transport by P‐170 in KB‐V1 plasma membrane vesicles

Isabelle H. Lelong, R. Padmanabhan, Elizabeth Lovelace, I Pastan, Michael M. Gottesman

FEBS Letters · 1992 · 36 citations · 12 references

DOI

Concepts

Abstract

Purified plasma membrane vesicles isolated from multidrug-resistant human KB-V1 cells accumulate [3H]vinblastine in an energy-dependent manner. The accumulation of [3H]vinblastine in the presence of ATP is a saturable process. ATP can be replaced by other purine nucleotide triphosphates, of which GTP is the most efficient.

References

12

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Marion M. Bradford · Analytical Biochemistry · 1976 · 211.2K citations

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

R. L. Juliano, Victor Ling · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1976 · 3.3K citations

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ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

Masaru Horio, Michael M. Gottesman, Ira Pastan · Proceedings of the National Academy of Sciences · 1988 · 480 citations · Full text

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Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

Donglai Shen, Carol Cardarelli, Jinyoung Hwang et al. · Journal of Biological Chemistry · 1986 · 467 citations · Full text

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