Ultrastructural localization of Alzheimer amyloid ?/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Life Sciences, Molecular Biology, Neuroscience +14

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Marie‐Christine Chartier‐Harlin, Fiona Crawford, Henry Houlden et al. · Nature · 1991 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +16

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Jill R. Murrell, Martin R. Farlow, Bernardino Ghetti et al. · Science · 1991 · 1.1K citations

Life Sciences, Genetics, Neurology +17

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Nobuya Kitaguchi, Yasuyuki Takahashi, Yasuo Tokushima et al. · Nature · 1988 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +16