Interleukin-10 determines viral clearance or persistence in vivo

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 3.9K citations

T-regulatory Cell, Immunology, Virology +8

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela et al. · Nature · 2006 · 2.6K citations

T-cell Exhaustion, Autoimmune Disease, Pd-1 Expression +10

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Allan Zajac, Joseph N. Blattman, Kaja Murali‐Krishna et al. · The Journal of Experimental Medicine · 1998 · 1.9K citations · Full text

Immunological Memory, Viral Persistence, Autoimmune Disease +15

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

David Fiorentino, Albert Zlotnik, Paulo Vieira et al. · The Journal of Immunology · 1991 · 1.9K citations · Full text

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

E. John Wherry, Joseph N. Blattman, Kaja Murali‐Krishna et al. · Journal of Virology · 2003 · 1.6K citations · Full text

T-regulatory Cell, Viral Immunity, Immunology +20