Concepedia

Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—A comparison with other phenothiazines

Jacek Wójcikowski, J Boksa, Władysława A. Daniel

Biochemical Pharmacology · 2010 · 59 citations · 28 references

DOI

Concepts

References

28

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

Kim Brøsen, Erik Skjelbo, Birgitte Buur Rasmussen et al. · Biochemical Pharmacology · 1993 · 371 citations

, , +7

Progress in drug metabolism

Food and Cosmetics Toxicology · 1977 · 304 citations

, , +4

Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches

Karthik Venkatakrishnan, Lisa L. von Moltke, Michael H. Court et al. · Drug Metabolism and Disposition · 2000 · 197 citations

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.

A. Lemoine, Jean‐Charles Gautier, Daniel Azoulay et al. · Molecular Pharmacology · 1993 · 178 citations