Concepedia

Design, synthesis, and structure–activity relationship studies of new phenolic DNA gyrase inhibitors

Thomas Lübbers, Peter Angehrn, Hans Gmünder, Silvia Herzig

Bioorganic & Medicinal Chemistry Letters · 2006 · 82 citations · 13 references

DOI

Concepts

References

13

Crystal structure of an N-terminal fragment of the DNA gyrase B protein

Dale B. Wigley, G.J. Davies, E.J. Dodson et al. · Nature · 1991 · 524 citations

, , +14

Antibiotic and Chemotherapy

The Medical Journal of Australia · 1965 · 432 citations

Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Hans-Joachim Boehm, Markus Boehringer, Daniel Bur et al. · Journal of Medicinal Chemistry · 2000 · 379 citations

, , +16

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography.

Richard J. Lewis, Okram Mukherjee Singh, Clare V. Smith et al. · The EMBO Journal · 1996 · 331 citations · Full text

, , +5

The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase:  A Thermodynamic and Crystallographic Study

Geoffrey A. Holdgate, Alan Riboldi‐Tunnicliffe, Walter H.J. Ward et al. · Biochemistry · 1997 · 208 citations

, , +17