Concepedia

Mitochondrial Abnormalities in Patients with Primary Open-Angle Glaucoma

Khaled K. Abu‐Amero, José Morales, Thomas M. Bosley

Investigative Ophthalmology & Visual Science · 2006 · 331 citations · 22 references

DOI

Abstract

These results reveal a spectrum of mitochondrial abnormalities in patients with POAG, implicating oxidative stress and implying that mitochondria dysfunction may be a risk factor for POAG. This concept may open up new experimental and therapeutic opportunities.

References

22

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Cécile Delettre, Guy Lenaers, Jean‐Michel Griffoin et al. · Nature Genetics · 2000 · 1.4K citations

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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

Christiane Alexander, Marcela Votruba, Ulrike E. A. Pesch et al. · Nature Genetics · 2000 · 1.3K citations

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Prediction of deleterious human alleles

Shamil Sunyaev · Human Molecular Genetics · 2001 · 1K citations

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Accounting for Human Polymorphisms Predicted to Affect Protein Function

Pauline C. Ng, Steven Henikoff · Genome Research · 2002 · 700 citations · Full text

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MITOMAP: a human mitochondrial genome database--2004 update

Martin Brandon · Nucleic Acids Research · 2004 · 568 citations · Full text