Annals of Clinical Biochemistry International Journal of Laboratory Medicine · 2006 · 13 citations · 6 references
Life SciencesGeneticsImmunologyHuman GeneticsImmunogeneticsMedical GeneticsChagas DiseaseHla TypingMajor Histocompatibility ComplexMolecular TypingChagas CardiomyopathyHla Allele PolymorphismHla AllelesHla Class Ii MoleculesHla Class Ii TypingHla Risk AllelesTrypanosoma Cruzi InfectionTrypanosome Infections
DNA typing of human lymphocyte antigen (HLA)-dicloro-1-[beta]-D-ribofuranosyl-benzimidazole 1 (DRB1) alleles in 35 individuals serologically positive for T. cruzi and in 41 healthy controls was performed. DRB1*0409 allele was significantly more prevalent in seropositive individuals, with a trend being also observed for the DRB1*0701 and DRB1*1503 alleles. Although statistically insignificant, the latter was found more frequent in cases with cardiomyopathy.
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