Concepedia

Effect of a Novel Nonviral Gene Delivery of BMP-2 on Bone Healing

P. Schwabe, Stefan Greiner, R. Ganzert, Johann K. Eberhart, Kimberly A. Dahn, A. Stemberger, Christian Plank, G. Schmidmaier, Britt Wildemann

The Scientific World JOURNAL · 2012 · 27 citations · 32 references

DOIFull text

Open access

Abstract

A positive effect on fracture healing by nonviral BMP-2 plasmid application from COPROG-coated implants could be shown in this study; however, the effect of the vector may be improved with higher plasmid concentrations. Transfection showed no biodistribution to distant organs and was considered to be safe.

References

32

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A. M. Parfitt, Marc K. Drezner, Francis H. Glorieux et al. · Journal of Bone and Mineral Research · 1987 · 5K citations

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Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units

A. M. Parfitt, M. K. Drezner, Francis H. Glorieux et al. · Journal of Bone and Mineral Research · 1987 · 3.3K citations

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RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 FOR TREATMENT OF OPEN TIBIAL FRACTURES

S. Govender, Cristina Csimma, Harry K. Genant et al. · Journal of Bone and Joint Surgery · 2002 · 1.3K citations

Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions

Gary E. Friedlaender, Clayton R. Perry, J. Dean Cole et al. · Journal of Bone and Joint Surgery · 2001 · 959 citations

Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

Jeffrey Bonadio, Elizabeth Smiley, Pravin Patil et al. · Nature Medicine · 1999 · 643 citations

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