Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe et al. · Nature · 2004 · 1.7K citations · Full text

Medicine, Biochemistry, Endocrinology +14

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Chunli Yu, Yan Chen, Gary W. Cline et al. · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

Life Sciences, Biochemistry, Physiology +17

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

Vincent Aguirre, Tohru Uchida, Lynne Yenush et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Vincent Aguirre, Eric D. Werner, Jodel Giraud et al. · Journal of Biological Chemistry · 2002 · 985 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

Liangyou Rui, Vincent Aguirre, Jason K. Kim et al. · Journal of Clinical Investigation · 2001 · 600 citations · Full text

Life Sciences, Biochemistry, Endocrinology +14