The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

G. Dark, S A Hill, Vivien E. Prise et al. · PubMed · 1997 · 624 citations

Medicine, Oncology, Pharmacology +13

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit et al. · Biochemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

George R. Pettit, Sheo B. Singh, Michael R. Boyd et al. · Journal of Medicinal Chemistry · 1995 · 391 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

G. M. Tozer, Vivien E. Prise, John Wilson et al. · PubMed · 1999 · 324 citations

Medicine, Oncology, Pharmacology +17

Structure-Activity Analysis of the Interaction of Curacin A, the Potent Colchicine Site Antimitotic Agent, with Tubulin and Effects of Analogs on the Growth of MCF-7 Breast Cancer Cells

Pascal Verdier‐Pinard, Jing‐Yu Lai, Hae-Dong Yoo et al. · Molecular Pharmacology · 1998 · 284 citations

Medicine, Medicinal Chemistry, Pharmacology +17