Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +17

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Life Sciences, Biology, Cell Biology +12

Essential role for oncogenic Ras in tumour maintenance

Lynda Chin, Alice Tam, Jason H. Pomerantz et al. · Nature · 1999 · 872 citations

Medicine, Cancer Biology, Oncology +16

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases

Arup K. Indra, Xavier Warot, Jacques Brocard et al. · Nucleic Acids Research · 1999 · 763 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

E. Elizabeth Patton, Hans R. Widlund, Jeffery L. Kutok et al. · Current Biology · 2005 · 672 citations · Full text

Medicine, Genetics, Oncology +14