Organic & Biomolecular Chemistry · 2010 · 10 citations · 10 references
Natural SciencesBiotechnologyChemistryOrganic ChemistryProtein EngineeringBioconjugation ChemistryProtein ChemistryBioconjugation Method DevelopmentCarboxylic Acid Derivative SynthesisStructure-property Relationships In Dyes
We present an efficient method to synthesize three new asymmetric trimethine cyanine dyes containing only one carboxylic acid group for bioconjugation. Two of them have better protein labeling performance than other conventional cyanine dyes due to their particular structure design.
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