Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Gerd A. Kullak‐Ublick, Manfred G. Ismair, Bruno Stieger et al. · Gastroenterology · 2001 · 724 citations · Full text

Life Sciences, Biochemistry, Pharmacology +8

Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine

George K. Dresser, David G. Bailey, Brenda F. Leake et al. · Clinical Pharmacology & Therapeutics · 2002 · 606 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel et al. · Biochemical and Biophysical Research Communications · 2003 · 503 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Effect of grapefruit juice on digoxin pharmacokinetics in humans

Laurent Becquemont, Céline Verstuyft, Reinhold Kerb et al. · Clinical Pharmacology & Therapeutics · 2001 · 389 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

Stephan R. Vavricka, Jessica van Montfoort, Huy Riêm Ha et al. · Hepatology · 2002 · 372 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17