Proceedings of the National Academy of Sciences · 1987 · 39 citations · 34 references
Life SciencesImmunologyOncologyCancer ImmunologyImmunogeneticsTumor ImmunologyHistocompatibilityHistocompatibility AntigensMajor Histocompatibility ComplexT Cell Responses To TumorsTumor AntigensTumor-associated AntigensAllogeneic Antigen SpecificityHla Antigen ExpressionImmune-mediated Cell LysisImmunogenicity Of Tumor AntigensLymphocytic ChoriomeningitisMajor Histocompatibility Complex Class I RecognitionMajor Histocompatibility Complex Class I RestrictionTumor Rejection Antigens
Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.
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Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens
Vernon T. Oi, Pauline Jones, James W. Goding et al. · 1979 · 979 citations