Effect of VKORC1 –1639 G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients

Effect of <i>VKORC1</i> Haplotypes on Transcriptional Regulation and Warfarin Dose

Mark J. Rieder, Alex P. Reiner, Brian F. Gage et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

Life Sciences, Genetics, Pharmacology +14

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

Guruprasad P. Aithal, Christopher P. Day, Patrick Kesteven et al. · The Lancet · 1999 · 1.2K citations

Medicine, Pharmacokinetics, Pharmacology +12

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations

Medicine, Genetics, Molecular Genetics +12

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

Mitchell K. Higashi · JAMA · 2002 · 1.1K citations

Medicine, Genetics, Pharmacology +17

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Elizabeth Sconce, Tayyaba Khan, Hilary Wynne et al. · Blood · 2005 · 947 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17