Concepedia

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK

Oliver Rath, Sungdae Park, Huihui Tang, Mark J. Banfield, R.L. Brady, Yie Chia Lee, John David Dignam, John M. Sedivy, Walter Kölch, Kam C. Yeung

Cellular Signalling · 2008 · 52 citations · 17 references

DOI

Concepts

References

17

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Walter Kölch · Biochemical Journal · 2000 · 1.4K citations · Full text

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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

Kam C. Yeung, Thomas Seitz, Shengfeng Li et al. · Nature · 1999 · 923 citations

, , +9

Regulation and Role of Raf-1/B-Raf Heterodimerization

Linda Rushworth, Alison D. Hindley, Eric O’Neill et al. · Molecular and Cellular Biology · 2006 · 417 citations · Full text

, , +15

Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

Kam C. Yeung, Petra Janosch, Brian W. McFerran et al. · Molecular and Cellular Biology · 2000 · 403 citations

, , +17

Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

Kristina Lorenz, Martin J. Lohse, Ursula Quitterer · Nature · 2003 · 398 citations

, , +8