Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L. Masters, Aisling Dunne, Shoba Subramanian et al. · Nature Immunology · 2010 · 1.3K citations · Full text

Life Sciences, Endocrinology, Immunology +14

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.

Garth J. S. Cooper, Anthony C. Willis, Anne Clark et al. · Proceedings of the National Academy of Sciences · 1987 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Kathrin Maedler, Frédéric Ris, José Oberholzer et al. · Journal of Clinical Investigation · 2002 · 992 citations · Full text

Life Sciences, Cell Biology, Endocrinology +17

Amyloid ion channels: A common structural link for protein-misfolding disease

Arjan P. Quist, Ivo Doudevski, Hai Lin et al. · Proceedings of the National Academy of Sciences · 2005 · 982 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

Per Westermark, Christer Wernstedt, Erik Wilander et al. · Proceedings of the National Academy of Sciences · 1987 · 980 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17