Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

Yukihiro Fujita, Rhonda D. Wideman, Madeleine Speck, +5

American Journal of Physiology-Endocrinology and Metabolism

NutritionGlycobiologySweet TasteDigestive TractInsulin Signaling +15

The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis

Scott D. Covey, Rhonda D. Wideman, Christine M. McDonald, +7

Cell Metabolism

Metabolic SyndromeInsulin SignalingSignal TransductionDiabetesPhysiology +9

Insulin Inhibits IL-10–Mediated Regulatory T Cell Function: Implications for Obesity

Jonathan M. Han, Scott J. Patterson, Madeleine Speck, +2

The Journal of Immunology

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

Nicholas A.J. Dawson, Isaac Rosado‐Sánchez, Gherman Novakovsky, +9

Science Translational Medicine

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat

Shalea Piteau, Amy Olver, Su‐jin Kim, +8

Biochemical and Biophysical Research Communications

Metabolic SyndromeNeuropeptidesInsulin SignalingMolecular PhysiologyZucker Rat +10

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

Dominika Nąckiewicz, Meixia Dan, Wei He, +10

Diabetologia

InflammationToll-like ReceptorsCytokineAutoimmune DiseaseImmunology +6

Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients

A Sicard, Caroline Lamarche, Madeleine Speck, +6

American Journal of Transplantation

Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1

Madeleine Speck, Young Min Cho, Ali Asadi, +2

American Journal of Physiology-Endocrinology and Metabolism

GastroenterologySurgeryGlucose ToleranceInsulin SignalingGastrointestinal Peptide Hormone +18

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in T regulatory cells

Nicholas A.J. Dawson, Caroline Lamarche, Romy E. Hoeppli, +10

JCI Insight

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

Frank K. Huynh, Jasna Levi, Heather C. Denroche, +7

Diabetes