Concepedia

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

Nicholas A.J. Dawson, Isaac Rosado‐Sánchez, Gherman Novakovsky, Vivian Fung, Qing Huang, Emma McIver, Grace Y. Sun, Jana Gillies, Madeleine Speck, Paul C. Orban,

Science Translational Medicine · 2020 · 144 citations · 66 references

DOI

Concepts

Abstract

Comparison of 10 co-receptor variant CARs revealed a requirement for CD28wt for optimal suppression by human regulatory T cells.

References

66

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern et al. · Nature Medicine · 2015 · 1.8K citations · Full text

, , +17

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi et al. · Nature Immunology · 2002 · 1.7K citations

, , +14

PD-1 <sup>+</sup> regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Takahiro Kamada, Yosuke Togashi, Christopher Tay et al. · Proceedings of the National Academy of Sciences · 2019 · 1K citations · Full text

, , +17

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

KR Cooke, Lester Kobzik, TR Martin et al. · Blood · 1996 · 986 citations · Full text

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Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines

Geoffrey R. Hill, James M. Crawford, Kenneth R. Cooke et al. · Blood · 1997 · 832 citations · Full text

, , +17