Vasodilation produced by prostacyclin (PGI2) and 9(0)-thiaprostacyclin (PGI2-S) in the caninen femoral circulation

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

Gregory J. Dusting, Salvador Moncada, John R. Vane · Prostaglandins · 1977 · 412 citations

Medicine, Cardiology, Pharmacology +14

Prostacyclin (PGI2) is a weak contractor of coronary arteries of the pig

Gregory J. Dusting, Salvador Moncada, John R. Vane · European Journal of Pharmacology · 1977 · 60 citations

Medicine, Cardiology, Clinical Cardiology +10