INDIRECT RECOGNITION AND ANTIBODY PRODUCTION AGAINST A SINGLE MISMATCHED HLA-A2-TRANSGENIC MOLECULE PRECEDE THE DEVELOPMENT OF OBLITERATIVE AIRWAY DISEASE IN MURINE HETEROTOPIC TRACHEAL ALLOGRAFTS1

Abstract

These results show that sensitization of CD4+ T cells against the mismatched HLA-A2 alloantigen precedes the development of anti-HLA antibodies as well as OAD, suggesting an important role for alloreactive CD4(+) T-cell activation and alloantibody development in the immunopathogenesis of OAD.