Concepedia

The AGC Kinase Inhibitor H89 Attenuates Airway Inflammation in Mouse Models of Asthma

Laurent L. Reber, François Daubeuf, Simona Nemska, Nelly Frossard

PLoS ONE · 2012 · 23 citations · 36 references

DOIFull text

Open access

Abstract

Taken together, our findings implicate that blockade of AGC kinases may have therapeutic potential for the treatment of allergic airway inflammation.

References

36

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 4.1K citations · Full text

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 3.1K citations

, , +17

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

Takashi Chijiwa, Akihiko Mishima, Masatoshi Hagiwara et al. · Journal of Biological Chemistry · 1990 · 1.5K citations · Full text

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

Eckard Hamelmann, Jürgen Schwarze, Katsuyuki Takeda et al. · American Journal of Respiratory and Critical Care Medicine · 1997 · 1.3K citations