Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

KIM DOHOON, KIM SUNHONG, YOON SANG‐OH et al. · The FASEB Journal · 2001 · 490 citations

Life Sciences, Cell Biology, Oncology +17

Activation of PI3K‐Akt signaling pathway promotes prostate cancer cell invasion

Sanjeev Shukla, Gregory T. MacLennan, Douglas J. Hartman et al. · International Journal of Cancer · 2007 · 314 citations

Medicine, Cell Biology, Oncology +16

Tumors and Fibrinogen

P. J. Simpson‐Haidaris, Brian J. Rybarczyk · Annals of the New York Academy of Sciences · 2001 · 300 citations

Medicine, Cell Biology, Oncology +15

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Pin-Shern Chen, Yuan‐Wei Shih, Hsiang-Ching Huang et al. · PLoS ONE · 2011 · 221 citations · Full text

Medicine, Oncology, Pharmacology +15