Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Tumor Biology, Hypoxia-inducible Factors, Oxygen-dependent Proteolysis +9

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Nancy C. Andrews, Douglas V. Faller · Nucleic Acids Research · 1991 · 2.3K citations · Full text

Dna Sequencing, Mammalian Cells, Natural Sciences +10

Expression of hypoxia-inducible factor 1? in brain tumors

David Zagzag, Hua Zhong, Joanne M. Scalzitti et al. · Cancer · 2000 · 596 citations

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Qing Xu, Jon Briggs, Sungman Park et al. · Oncogene · 2005 · 576 citations

Developmental Biology, Signaling Pathway, Cell Regulation +9

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

Xiang Xu, Ya‐Lin Sun, Timothy Hoey · Science · 1996 · 480 citations

Structural Bioinformatics, Genetics, Signal Recognition +22