Antimicrobial activity of bovine bactericidal permeability–increasing protein–derived peptides against gram-negative bacteria isolated from the milk of cows with clinical mastitis

Abstract

bBPI(9,099, 148,161) is a potent neutralizer of the highly proinflammatory molecule bacterial LPS and has antimicrobial activity against a variety of gram-negative bacteria. The ability of bBPI(9099,148161) to retain antimicrobial activity in serum suggests a potential therapeutic application for this peptide in the management of gram-negative septicemia.