Concepedia

An Asymmetric Synthesis of the ABC Ring System of 8-Demethyltaxoids from Optically Active 8-Membered Ring Compound <i>via</i> Intramolecular Aldol and Pinacol Coupling Reactions

Isamu Shiina, Toshihiro Nishimura, Naoto Ohkawa, Hiroki Sakoh, Koji Nishimura, Katsuyuki Saitoh, Teruaki Mukaiyama

Chemistry Letters · 1997 · 19 citations · 4 references

DOI

Abstract

Abstract Optically active novel taxoids were efficiently synthesized from 8-membered ring compound 3 by successive constructions of BC and ABC ring systems via each intramolecular aldol and intramolecular pinacol coupling reactions.

References

4

Total synthesis of taxol

K. C. Nicolaou, Zhen Yang, Jimei Liu et al. · Nature · 1994 · 1.1K citations

, , +1

First total synthesis of taxol. 1. Functionalization of the B ring

Robert A. Holton, Carmen Somoza, Hyeong Baik Kim et al. · Journal of the American Chemical Society · 1994 · 627 citations

, , +14

First total synthesis of taxol. 2. Completion of the C and D rings

Robert A. Holton, Hyeong Baik Kim, Carmen Somoza et al. · Journal of the American Chemical Society · 1994 · 521 citations

, , +13

A Total Synthesis of Taxol

John J. Masters, J. T. Link, Lawrence B. Snyder et al. · Angewandte Chemie International Edition in English · 1995 · 214 citations

, , +7