Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Host Response, Toll-like Receptors, Signal Transduction +10

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

Koji Ohashi, Volker Burkart, Stefanie B. Flohé et al. · The Journal of Immunology · 2000 · 1.6K citations · Full text

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Christian Termeer, Frauke Benedix, Jonathan P. Sleeman et al. · The Journal of Experimental Medicine · 2002 · 1.3K citations · Full text

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

Yoshinori Okamura, Michiko Watari, Elliot S. Jerud et al. · Journal of Biological Chemistry · 2001 · 1.2K citations · Full text

Tlr4 Accessory Protein, Innate Immune System, Immunology +19