Overexpression of the p16 Cell Cycle Inhibitor in Breast Cancer is Associated with a More Malignant Phenotype

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

James G. Herman, Adrian Merlo, Li Mao et al. · PubMed · 1995 · 1.4K citations

Epigenetic Change, Dna Methylation, Aberrant Dna Methylation +17

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

Ute M. Moll, G Riou, Arnold J. Levine · Proceedings of the National Academy of Sciences · 1992 · 580 citations · Full text

Distinct Mechanisms, Breast Oncology, Pathology +16

Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

L. I. Huschtscha, Jane R. Noble, Axel A. Neumann et al. · PubMed · 1998 · 158 citations

Epigenetic Change, Cancer Biology, Epigenetics +22

High frequency of aberrant p16(INK4A) expression in human breast cancer.

Joseph Geradts, P. Wilson · PubMed · 1996 · 137 citations

Cyclin E, a redundant cyclin in breast cancer

Julie Gray-Bablin, Juan Zalvide, MM Fox et al. · Proceedings of the National Academy of Sciences · 1996 · 120 citations · Full text