Mutagenicity of 4-Aminobiphenyl and 4-Acetylaminobiphenyl in Salmonella typhimurium Strains Expressing Different Levels of N-Acetyltransferase

Revised methods for the Salmonella mutagenicity test

Dorothy M. Maron, Bruce N. Ames · Mutation Research/Environmental Mutagenesis and Related Subjects · 1983 · 7.4K citations

Pharmacy, Microbiology, Toxicology +7

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER

RaymondA Cartwright, HowardJ. Rogers, D Barham-Hall et al. · The Lancet · 1982 · 494 citations

Medicine, Oncology, Urology +10

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

Nicholas P. Lang, Marguerite A. Butler, Joyce Massengill et al. · PubMed · 1994 · 392 citations

Medicine, Pharmacology, Toxicology +17

Cigarette Smoking, N-Acetyltransferase 2 Genetic Polymorphisms, and Breast Cancer Risk

Christine B. Ambrosone · JAMA · 1996 · 333 citations

Life Sciences, Genetics, Molecular Genetics +17